CONCEPTUAL DESIGN OF A GAUGE-CHANGEABLE LOCOMOTIVE BOGIE STRUCTURE

Conceptual design of a gauge-changeable locomotive bogie structure

To facilitate through operation on railway lines with different gauges, stedy stand aid this paper presents the design of a gauge-changeable locomotive bogie along with wheelsets that are adaptable to gauge changes between 1 000 mm and 1 435 mm.Based on a wheel-locking mode that was selected after analyzing various locking and unlocking methods, th

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Glycerol-weighted chemical exchange saturation transfer nanoprobes allow 19F/1H dual-modality magnetic resonance imaging-guided cancer radiotherapy

Abstract Recently, radiotherapy (RT) has entered a new realm of precision cancer therapy with the introduction of magnetic resonance (MR) imaging guided radiotherapy systems into the clinic.Nonetheless, identifying an optimized radiotherapy time window (ORTW) is still critical for the best therapeutic efficacy of RT.Here we describe pH and O2 dual-

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Trehalose itself plays a critical role on lipid metabolism: Trehalose increases jejunum cytoplasmic lipid droplets which negatively correlated with mesenteric adipocyte size in both HFD-fed trehalase KO and WT mice

Abstract Background Trehalose is a functional disaccharide that has anti-metabolic activities such as suppression of adipocyte hypertrophy in mice and alleviation of impaired glucose tolerance in humans.Trehalase hydrolyzes trehalose in the small intestine into two glucose molecules.In this study, we investigated whether trehalose can suppress adip

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